Motor Neurons

Gain a deeper understanding of the complexities of neuronal signaling and tease apart variations due to age, gender, and donor variability with neurons derived from human iPS cells.

  • Quick-Neuron™ Motor - Human iPSC-derived Neurons give you access to the same cells with every order for more biologically relevant and reproducible studies
  • Quick-Neuron™ Motor Kits provide you with a quick and easy way to turn your iPS cells into motor neurons.


  • ~ 1 week differentiation
  • Functionally validated
  • Highly pure population
  • No genetic footprint
  • Differentiation Kits and Differentiated Cells available
  • Multiple donors and disease types available


Differentiation kit workflow (upper: SeV kit, lower: mRNA kit)

Representative images of Quick-Neuron Motor - SeV Kit cell cultures on days 1-7 post-differentiation (scale bar = 100 μm).

iPSC-derived cells workflow

Representative images of Quick-Neuron™ Motor - Human iPSC-derived Neurons on days 1-3 post-thaw (scale bar = 100 μm).

Immunofluorescent staining of Quick-Neuron™ Cholinergic - SeV cell culture shows typical neurite growth and expression of the pan-neuronal marker TUBB3 as well as HB9 on day 10 post-differentiation (scale bars = 100 μm)

Immunofluorescent staining of Quick-Neuron™ Motor - SeV cell culture shows typical neurite growth and expression of the pan-neuronal marker TUBB3 and CHAT on day 7 post-differentiation (scale bars = 100 μm)

Real-time quantitative PCR analysis of expression levels of genes CHAT, HB9, and ISL1 were examined. The graph shows gene expression in Quick-Neuron™ Motor - SeV culture on day 10 post-differentiation.The relative gene expression is normalized to phosphoglycerate kinase 1 (PGK1), and then calculated as a fold induction relative to undifferentiated hPSCs as a control. Error bars show standard deviation.

Motor Neuron Differentiation Kits

Our Quick-Neuron™ Motor - SeV and mRNA Kits (small and large sizes available) allow researchers to quickly, easily, and efficiently differentiate their iPS or ES cell line of choice into motor neurons. The kits utilize temperature sensitive Sendai virus and synthetic messenger RNA (syn-mRNA) to deliver our proprietary cocktail of transcription factors that induce differentiation without leaving a genetic footprint.

iPSC-derived Motor Neurons

Elixirgen Scientific’s Quick-Neuron™ Motor - Human iPSC-derived Neurons are created using human iPS cells made available through a license from The California Institute for Regenerative Medicine (CIRM).

The CIRM iPS cell repository includes over 1,500 iPS cell lines, so please contact us if you would like motor neurons derived from a specific donor cell line. Every lot of iPSCs is differentiated into motor neurons using our proprietary transcription factor-based technology that is “footprint-free” and delivers functional, high-quality cells.

Frequently Asked Questions

Do I need a license to use Elixirgen’s iPSC-derived cells and/or differentiation reagent kits?

No. The use of differentiated cells or kits provided by Elixirgen Scientific does not require any additional license from other parties for any type of use, except for use in humans or for therapeutic or diagnostic use. Check out our license statement in Resource section for further detail.

What sizes of Quick-Neuron™ Excitatory - Human iPSC-derived Neurons are available?

Off the shelf, we offer small (>1 million viable cryopreserved cells) and large (5x >1 million viable cryopreserved cells) sizes. If you are looking for a larger quantity, please contact us for pricing information.

Should I use an mRNA- or SeV-based differentiation kit?

Both delivery methods provide robust “footprint-free,” non-integrating expression of the transcription factors, although each kit uses a slightly different workflow. Based on our data, the differentiation efficiency between an mRNA-based and a SeV-based kit is similar. For example, the percentages of TUBB3+ neurons differentiated using Quick-Neuron™ Motor mRNA- and SeV-based kits were 93% and 88%, respectively.

We recommend the mRNA-based neuron differentiation kits for labs with experience culturing iPSCs/ESCs, as the workflow involves slightly more manipulation of fragile differentiating cells than the SeV-based kits. The SeV-based kits are better for labs with little experience culturing iPSCs/ESCs, although they must be used with BSL-2 safety measures and may require prior approval from your Institutional Biosafety Committee (IBC).

What sizes of Quick-Neuron™ differentiation kits are available?

Off the shelf, we offer small and large iPSC neuronal differentiation kits. The small size is best suited for single cell, imaging analyses, and pilot studies while the large size is best for applications such as high throughput screening and RNA sequencing.